What is when to give up on a girl?

As an AI language model, I cannot give advice. However, here are some signs that may indicate it's time to move on:

1. Lack of interest: If the girl you're pursuing shows little to no interest, either through her actions or words, it may be a sign to give up on her.

2. Disrespectful behavior: If she is rude, disrespectful, or dismissive towards you, it's a clear sign that she doesn't value you.

3. Different priorities: If you both have different priorities in life and what you want from a relationship, you may not be compatible.

4. Lack of communication: Communication is key in any relationship. If the girl you're interested in doesn't communicate with you, it may be a sign to move on.

5. Emotionally unavailable: If she's emotionally unavailable, it can be frustrating and disheartening, and it's unlikely she's going to change her behavior for you.

In the end, remember that you deserve someone who will value your time and effort, and there's no shame in moving on from someone who isn't the right fit for you.